Last edition Elsevier Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms.
Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.
Last Edition
ISBN 13:h9781259644030
Imprint:h McGraw-Hill
Language:hEnglish
Authors:hJoseph Loscalzo
Pub Date:h11/2018
Pages:h4400
Illus:hIllustrated
Weight:h6.078.00 grams
Size:h226 X 284 mm
Product Type:hHardcover
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- • Essential for practice and education, the landmark 20th Edition features:
- • Thoroughly revised content?covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s.
- • Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
- • State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments.
- • Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease.
- • Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
- • All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals.
- • New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine? Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
- • Important and timely new chapters?such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more?offer the very latest, definitive perspectives on must-know topics in medical education and practice.
- • Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforc
- J. Larry Jameson, MD, PhD Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania
- Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Dennis L. Kasper, MD William Ellery Channing Professor of Medicine and Professor of Microbiology and Immunobiology, Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts
- Stephen L. Hauser, MD Director, UCSF Weill Institute for Neurosciences;
- Robert A. Fishman Distinguished Professor, Department of Neurology, University of California, San Francisco, San Francisco, California
- Dan L. Longo, MD Professor of Medicine, Harvard Medical School; Senior Physician, Brigham and Women’s Hospital; Deputy Editor, New England Journal of Medicine, Boston, Massachusetts
- Joseph Loscalzo, MD, PhD Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Women’s Hospital, Boston, Massachusetts
- CONTRIBUTORS PREFACE
- Part 1: The Profession of Medicine1 The Practice of Medicine The Editors
- 2 Promoting Good Health Donald M. Lloyd-Jones, Kathleen M. McKibbin
- 3 Decision-Making in Clinical Medicine Daniel B. Mark, John B. Wong
- 4 Screening and Prevention of Disease Katrina A. Armstrong, Gary J. Martin
- 5 Health Care Systems in Developed Countries Richard B. Saltman
- 6 The Safety and Quality of Health Care David W. Bates
- 7 Racial and Ethnic Disparities in Health Care Joseph R. Betancourt, Alexander R. Green
- 8 Ethical Issues in Clinical Medicine Bernard Lo, Christine Grady
- 9 Palliative and End-of-Life Care Ezekiel J. Emanuel
- Part 2: Cardinal Manifestations and Presentation of Diseases
- Section 1: Pain
- 10 Pain: Pathophysiology and Management James P. Rathmell, Howard L. Fields
- 11 Chest Discomfort David A. Morrow
- 12 Abdominal Pain Danny O. Jacobs
- 13 Headache Peter J. Goadsby
- 14 Back and Neck Pain John W. Engstrom
- Section 2: Alterations in Body Temperature
- 15 Fever Charles A. Dinarello, Reuven Porat
- 16 Fever and Rash Elaine T. Kaye, Kenneth M. Kaye
- 17 Fever of Unknown Origin Chantal P. Bleeker-Rovers, Jos W. M. van der Meer
- Section 3: Nervous System Dysfunction
- 18 Syncope Roy Freeman
- 19 Dizziness and Vertigo Mark F. Walker, Robert B. Daroff
- 20 Fatigue Jeffrey M. Gelfand, Vanja C. Douglas
- 21 Neurologic Causes of "Weakness and Paralysis Michael J. Aminoff
- 22 Numbness, Tingling, and Sensory Loss Michael J. Aminoff
- 23 Gait Disorders, Imbalance and Falls Jessica M. Baker, Lewis R. Sudarsky
- 24 Confusion and Delirium S. Andrew Josephson, Bruce L. Miller
- 25 Dementia William W. Seeley, Bruce L. Miller
- 26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders M.-Marsel Mesulam
- 27 Sleep Disorders Thomas E. Scammell, Clifford B. Saper,
- Charles A. Czeisler
- Section 4: Disorders of Eyes, Ears, Nose, and Throat
- 28 Disorders of the Eye Jonathan C. Horton
- 29 Disorders of Smell and Taste Richard L. Doty, Steven M. Bromley
- 30 Disorders of Hearing Anil K. Lalwani
- 31 Sore Throat, Earache, and Upper Respiratory Symptoms Michael A. Rubin, Larry C. Ford, Ralph Gonzales
- 32 Oral Manifestations of Disease Samuel C. Durso
- Section 5: Alterations in Circulatory and Respiratory Functions
- 33 Dyspnea Rebecca M. Baron
- 34 Cough Christopher H. Fanta
- 35 Hemoptysis Anna K. Brady, Patricia A. Kritek
- 36 Hypoxia and Cyanosis Joseph Loscalzo
- 37 Edema Eugene Braunwald, Joseph Loscalzo
- 38 Approach to the Patient with a Heart Murmur Patrick T. O'Gara, Joseph Loscalzo
- 39 Palpitations Joseph Loscalzo
- Section 6: Alterations in Gastrointestinal Function
- 40 Dysphagia Ikuo Hirano, Peter J. Kahrilas
- 41 Nausea, Vomiting, and Indigestion William L. Hasler
- 42 Diarrhea and Constipation Michael Camilleri, Joseph A. Murray
- 43 Unintentional Weight Loss J. Larry Jameson
- 44 Gastrointestinal Bleeding Loren Laine
- 45 Jaundice Savio John, Daniel S. Pratt
- 46 Abdominal Swelling and Ascites Kathleen E. Corey, Lawrence S. Friedman
- Section 7: Alterations in Renal and Urinary Tract Function</li>
- 47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome John W. Warren
- 48 Azotemia and Urinary Abnormalities David B. Mount
- 49 Fluid and Electrolyte Disturbances David B. Mount
- 50 Hypercalcemia and Hypocalcemia Sundeep Khosla
- 51 Acidosis and Alkalosis Thomas D. DuBose, Jr.
- Section 8: Alterations in the Skin
- 52 Approach to the Patient with a Skin Disorder Kim B. Yancey, Thomas J. Lawley
- 53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley
- 54 Skin Manifestations of Internal Disease Jean L. Bolognia, Irwin M. Braverman
- 55 Immunologically Mediated Skin Diseases Kim B. Yancey, Thomas J. Lawley
- 56 Cutaneous Drug Reactions Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai
- 57 Photosensitivity and Other Reactions to Light Alexander G. Marneros, David R. Bickers
- Section 9: Hematologic Alterations
- 58 Interpreting Peripheral Blood Smears Dan L. Longo
- 59 Anemia and Polycythemia John W. Adamson, Dan L. Longo
- 60 Disorders of Granulocytes and Monocytes Steven M. Holland, John I. Gallin
- 61 Bleeding and Thrombosis Barbara A. Konkle
- 62 Enlargement of Lymph Nodes and Spleen Dan L. Longo
- Part 3: Pharmacology
- 63 Principles of Clinical Pharmacology Dan M. Roden
- 64 Pharmacogenomics Dan M. Roden
- Part 4: Oncology and Hematology
- Section 1: Neoplastic Disorders
- 65 Approach to the Patient with Cancer Dan L. Longo
- 66 Prevention and Early Detection of "Cancer Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer
- 67 Cancer Genetics Fred Bunz, Bert Vogelstein
- 68 Cancer Cell Biology Jeffrey W. Clark, Dan L. Longo
- 69 Principles of Cancer Treatment Edward A. Sausville, Dan L. Longo
- 70 Infections in Patients with Cancer Robert W. Finberg
- 71 Oncologic Emergencies Rasim Gucalp, Janice P. Dutcher
- 72 Cancer of the Skin Brendan D. Curti, Sancy Leachman, Walter J. Urba
- 73 Head and Neck Cancer Everett E. Vokes
- 74 Neoplasms of the Lung Leora Horn, Christine M. Lovly
- 75 Breast Cancer Daniel F. Hayes, Marc E. Lippman
- 76 Upper Gastrointestinal Tract Cancers Robert J. Mayer
- 77 Lower Gastrointestinal Cancers Robert J. Mayer
- 78 Tumors of the Liver and Biliary Tree Josep M. Llovet
- 79 Pancreatic Cancer Daniel D. Von Hoff
- 80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas Robert T. Jensen
- 81 Renal Cell Carcinoma Robert J. Motzer
- 82 Cancer of the Bladder and Urinary Tract Noah M. Hahn
- 83 Benign and Malignant Diseases of the Prostate Howard I. Scher, James A. Eastham
- 84 Testicular Cancer David J. Vaughn
- 85 Gynecologic Malignancies David Spriggs
- 86 Primary and Metastatic Tumors of the Nervous System Lisa M. DeAngelis, Patrick Y. Wen
- 87 Soft Tissue and Bone Sarcomas and Bone Metastases Shreyaskumar R. Patel
- 88 Carcinoma of Unknown Primary Gauri R. Varadhachary, James L. Abbruzzese
- 89 Paraneoplastic Syndromes: Endocrinologic/Hematologic J. Larry Jameson, Dan L. Longo
- 90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis Josep Dalmau, Myrna R. Rosenfeld
- 91 Late Consequences of Cancer and Its Treatment Carl E. Freter, Dan L. Longo
- Section 2: Hematopoietic Disorders
- 92 Hematopoietic Stem Cells David T. Scadden, Dan L. Longo
- 93 Iron Deficiency and Other Hypoproliferative Anemias John W. Adamson
- 94 Disorders of Hemoglobin Edward J. Benz, Jr.
- 95 Megaloblastic Anemias A. Victor Hoffbrand
- 96 Hemolytic Anemias Lucio Luzzatto
- 97 Anemia Due to Acute Blood Loss Dan L. Longo
- 98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia Neal S. Young
- 99 Polycythemia Vera and Other Myeloproliferative Neoplasms Jerry L. Spivak
- 100 Acute Myeloid Leukemia William Blum, Clara D. Bloomfield
- 101 Chronic Myeloid Leukemia Hagop Kantarjian, Jorge Cortes
- 102 Acute Lymphoid Leukemia Dieter Hoelzer
- 103 Chronic Lymphocytic Leukemia Jennifer A. Woyach, John C. Byrd
- 104 Non-Hodgkin's Lymphoma Caron A. Jacobson, Dan L. Longo
- 105 Hodgkin's Lymphoma Caron A. Jacobson, Dan L. Longo
- 106 Less Common Hematologic Malignancies Ayalew Tefferi, Dan L. Longo
- 107 Plasma Cell Disorders Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson
- 108 Amyloidosis John L. Berk, Vaishali Sanchorawala
- 109 Transfusion Biology and Therapy Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson
- 110 Hematopoietic Cell Transplantation Frederick R. Appelbaum
- Section 3: Disorders of Hemostasis
- 111 Disorders of Platelets and Vessel Wall Barbara A. Konkle
- 112 Coagulation Disorders Valder R. Arruda, Katherine A. High
- 113 Arterial and Venous Thrombosis Jane E. Freedman, Joseph Loscalzo
- 114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Jeffrey I. Weitz
- Part 5: Infectious Diseases
- Section 1: Basic Considerations in Infectious Diseases
- 115 Approach to the Patient with an Infectious Disease Neeraj K. Surana, Dennis L. Kasper
- 116 Molecular Mechanisms of Microbial Pathogenesis Gerald B. Pier
- 117 Approach to the Acutely Ill Infected Febrile Patient Tamar F. Barlam, Dennis L. Kasper
- 118 Immunization Principles and Vaccine Use Nancy Messonnier, Anne Schuchat, Lisa A. Jackson
- 119 Health Recommendations for International Travel Jay S. Keystone, Phyllis E. Kozarsky
- 120 Climate Change and Infectious Disease Aaron S. Bernstein
- Section 2: Clinical Syndromes: Community-Acquired Infections
- 121 Pneumonia Lionel A. Mandell, Richard G. Wunderink
- 122 Lung Abscess Rebecca M. Baron, Miriam Baron Barshak
- 123 Infective Endocarditis Adolf W. Karchmer
- 124 Infections of the Skin, Muscles, and Soft Tissues Dennis L. Stevens
- 125 Infectious Arthritis Lawrence C. Madoff
- 126 Osteomyelitis Werner Zimmerli
- 127 Intraabdominal Infections and Abscesses Miriam Baron Barshak, Dennis L. Kasper
- 128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque
- 129 Clostridium difficile Infection, Including Pseudomembranous Colitis Dale N. Gerding, Stuart Johnson
- 130 Urinary Tract Infections, Pyelonephritis, and Prostatitis Kalpana Gupta, Barbara W. Trautner
- 131 Sexually Transmitted Infections: Overview and Clinical Approach Jeanne M. Marrazzo, King K. Holmes
- 132 Encephalitis Karen L. Roos, Kenneth L. Tyler
- 133 Acute Meningitis Karen L. Roos, Kenneth L. Tyler
- 134 Chronic and Recurrent Meningitis Walter J. Koroshetz, Michael R. Wilson, Avindra Nath
- 135 Brain Abscess and Empyema Karen L. Roos, Kenneth L. Tyler
- 136 Infectious Complications of Bites Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff
- Section 3: Clinical Syndromes: Health Care-Associated Infections
- 137 Infections Acquired in Health Care Facilities Robert A. Weinstein
- 138 Infections in Transplant Recipients Robert W. Finberg, Joyce D. Fingeroth
- Section 4: Therapy for Bacterial Diseases
- 139 Treatment and Prophylaxis of Bacterial Infections David C. Hooper, Erica S. Shenoy, Christy A. Varughese
- 140 Bacterial Resistance to Antimicrobial Agents David C. Hooper
- Section 5: Diseases Caused by Gram-Positive Bacteria
- 141 Pneumococcal Infections David Goldblatt, Katherine L. O'Brien
- 142 Staphylococcal Infections Franklin D. Lowy
- 143 Streptococcal Infections Michael R. Wessels
- 144 Enterococcal Infections Cesar A. Arias, Barbara E. Murray
- 145 Diphtheria and Other Corynebacterial Infections William R. Bishai, John R. Murphy
- 146 Listeria monocytogenes Infections Elizabeth L. Hohmann, Daniel A. Portnoy
- 147 Tetanus C. Louise Thwaites, Lam Minh Yen
- 148 Botulism Agam K. Rao, Susan Maslanka
- 149 Gas Gangrene and Other Clostridial Infections Amy E. Bryant, Dennis L. Stevens
- Section 6: Diseases Caused by Gram-Negative Bacteria
- 150 Meningococcal Infections Andrew J. Pollard
- 151 Gonococcal Infections Sanjay Ram, Peter A. Rice
- 152 Haemophilus and Moraxella Infections Timothy F. Murphy
- 153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria Tamar F. Barlam, Dennis L. Kasper
- 154 Legionella Infections Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin
- 155 Pertussis and Other Bordetella Infections Karina A. Top, Scott A. Halperin
- 156 Diseases Caused by Gram-Negative Enteric Bacilli Thomas A. Russo, James R. Johnson
- 157 Acinetobacter Infections Rossana Rosa, L. Silvia Munoz-Price
- 158 Helicobacter pylori Infections John C. Atherton, Martin J. Blaser
- 159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species Reuben Ramphal
- 160 Salmonellosis David A. Pegues, Samuel I. Miller
- 161 Shigellosis Philippe J. Sansonetti, Jean Bergounioux
- 162 Infections Due to Campylobacter and Related Organisms Beth D. Kirkpatrick, Martin J. Blaser
- 163 Cholera and Other Vibrioses Matthew K. Waldor, Edward T. Ryan
- 164 Brucellosis Nicholas J. Beeching
- 165 Tularemia Jeannine M. Petersen, Paul S. Mead
- 166 Plague and Other Yersinia Infections Michael B. Prentice
- 167 Bartonella Infections, Including Cat-Scratch Disease Michael Giladi, Moshe Ephros
- 168 Donovanosis Nigel O'Farrell cSection 7: Miscellaneous Bacterial Infections
- 169 Nocardiosis Gregory A. Filice
- 170 Actinomycosis Thomas A. Russo
- 171 Whipple's Disease Thomas A. Russo
- 172 Infections Due to Mixed Anaerobic Organisms Neeraj K. Surana, Dennis L. Kasper
- Section 8: Mycobacterial Diseases
- 173 Tuberculosis Mario C. Raviglione
- 174 Leprosy Robert H. Gelber
- 175 Nontuberculous Mycobacterial Infections Steven M. Holland
- 176 Antimycobacterial Agents Divya Reddy, Max R. O'Donnell
- Section 9: Spirochetal Diseases
- 177 Syphilis Sheila A. Lukehart
- 178 Endemic Treponematoses Sheila A. Lukehart
- 179 Leptospirosis Jiri F. P. Wagenaar, Marga G. A. Goris
- 180 Relapsing Fever Alan G. Barbour
- 181 Lyme Borreliosis Allen C. Steere
- Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
- 182 Rickettsial Diseases David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie
- 183 Infections Due to Mycoplasmas R. Doug Hardy
- 184 Chlamydial Infections Charlotte A. Gaydos, Thomas C. Quinn
- Section 11: Viral Diseases: General Considerations
- 185 Medical Virology Fred Wang, Elliott Kieff
- 186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs Lindsey R. Baden
- Section 12: Infections Due to DNA Viruses
- 187 Herpes Simplex Virus Infections Lawrence Corey
- 188 Varicella-Zoster Virus Infections Richard J. Whitley
- 189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis Jeffrey I. Cohen
- 190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 Camille Nelson Kotton, Martin S. Hirsch
- 191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections Fred Wang
- 192 Parvovirus Infections Kevin E. Brown
- 193 Human Papillomavirus Infections Darron R. Brown, Aaron Ermel
- Section 13: Infections Due to DNA and RNA Respiratory Viruses
- 194 Common Viral Respiratory Infections James E. Crowe, Jr.
- 195 Influenza Peter F. Wright
- Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
- 196 The Human Retroviruses Dan L. Longo, Anthony S. Fauci
- 197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane
- Section 15: Infections Due to RNA Viruses
- 198 Viral Gastroenteritis Umesh D. Parashar, Roger I. Glass
- 199 Enterovirus, Parechovirus, and Reovirus Infections Jeffrey I. Cohen
- 200 Measles (Rubeola) Kaitlin Rainwater-Lovett, William J. Moss
- 201 Rubella (German Measles) Laura A. Zimmerman, Susan E. Reef
- 202 Mumps Steven A. Rubin
- 203 Rabies and Other Rhabdovirus Infections Alan C. Jackson
- 204 Arthropod-Borne and Rodent-Borne Virus Infections Jens H. Kuhn, Remi N. Charrel
- 205 Ebolavirus and Marburgvirus Infections Jens H. Kuhn
- Section 16: Fungal Infections
- 206 Diagnosis and Treatment of Fungal Infections John E. Edwards, Jr.
- 207 Histoplasmosis Chadi A. Hage, L. Joseph Wheat
- 208 Coccidioidomycosis Neil M. Ampel
- 209 Blastomycosis S. Travis King, Rathel L. Nolan, III
- 210 Cryptococcosis Arturo Casadevall
- 211 Candidiasis John E. Edwards, Jr.
- 212 Aspergillosis David W. Denning
- 213 Mucormycosis Brad Spellberg, Ashraf S. Ibrahim
- 214 Superficial Mycoses and Less Common Systemic Mycoses Carol A. Kauffman
- 215 Pneumocystis Infections Alison Morris, Henry Masur
- Section 17: Protozoal and Helminthic Infections: General Considerations
- 216 Introduction to Parasitic Infections Sharon L. Reed, Charles E. Davis
- 217 Agents Used to Treat Parasitic Infections Thomas A. Moore
- Section 18: Protozoal Infections
- 218 Amebiasis and Infection with Free-Living Amebae Rosa M. Andrade, Sharon L. Reed
- 219 Malaria Nicholas J. White, Elizabeth A. Ashley
- 220 Babesiosis Edouard Vannier, Peter J. Krause
- 221 Leishmaniasis Shyam Sundar
- 222 Chagas Disease and African Trypanosomiasis Francois Chappuis, Yves Jackson
- 223 Toxoplasma Infections Kami Kim
- 224 Protozoal Intestinal Infections and Trichomoniasis Peter F. Weller
- Section 19: Helminthic Infections
- 225 Introduction to Helminthic Infections Peter F. Weller
- 226 Trichinellosis and Other Tissue Nematode Infections Peter F. Weller
- 227 Intestinal Nematode Infections Peter F. Weller, Thomas B. Nutman
- 228 Filarial and Related Infections Thomas B. Nutman, Peter F. Weller
- 229 Schistosomiasis and Other Trematode Infections Birgitte Jyding Vennervald
- 230 Cestode Infections A. Clinton White, Jr., Peter F. Weller
- Part 6: Disorders of the Cardiovascular System
- Section 1: Introduction to Cardiovascular Disorders
- 231 Approach to the Patient with Possible Cardiovascular Disease Joseph Loscalzo
- 232 Basic Biology of the Cardiovascular System Joseph Loscalzo, Peter Libby, Calum A. MacRae
- 233 Epidemiology of Cardiovascular Disease Thomas A. Gaziano, J. Michael Gaziano
- Section 2: Diagnosis of Cardiovascular Disorders
- 234 Physical Examination of the Cardiovascular System Patrick T. O'Gara, Joseph Loscalzo
- 235 Electrocardiography Ary L. Goldberger
- 236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon
- 237 Diagnostic Cardiac Catheterization and Coronary Angiography Jane A. Leopold, David P. Faxon
- Section 3: Disorders of Rhythm</li>
- 238 Principles of Electrophysiology David D. Spragg, Gordon F. Tomaselli
- 239 The Bradyarrhythmias: Disorders of the Sinoatrial Node David D. Spragg, Gordon F. Tomaselli
- 240 The Bradyarrhythmias: Disorders of the Atrioventricular Node David D. Spragg, Gordon F. Tomaselli
- 241 Approach to Supraventricular Tachyarrhythmias Gregory F. Michaud, William G. Stevenson
- 242 Physiologic and Non-physiologic Sinus Tachycardia Gregory F. Michaud, William G. Stevenson
- 243 Focal Atrial Tachycardia Gregory F. Michaud, William G. Stevenson
- 244 Paroxysmal Supraventricular Tachycardias Gregory F. Michaud, William G. Stevenson
- 245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias Gregory F. Michaud, William G. Stevenson
- 246 Atrial Fibrillation Gregory F. Michaud, William G. Stevenson
- 247 Approach to Ventricular Arrhythmias Roy M. John, William G. Stevenson
- 248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm Roy M. John, William G. Stevenson
- 249 Sustained Ventricular Tachycardia William G. Stevenson, Roy M. John
- 250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation William G. Stevenson, Roy M. John
- 251 Electrical Storm and Incessant VT William G. Stevenson, Roy M. John
- Section 4: Disorders of the Heart
- 252 Heart Failure: Pathophysiology and Diagnosis Douglas L. Mann, Murali Chakinala
- 253 Heart Failure: Management Mandeep R. Mehra
- 254 Cardiomyopathy and Myocarditis Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo
- 255 Cardiac Transplantation and Prolonged Assisted Circulation Mandeep R. Mehra
- 256 Aortic Valve "Disease Patrick T. O'Gara, Joseph Loscalzo
- 257 Aortic Regurgitation Patrick T. O'Gara, Joseph Loscalzo
- 258 Mitral Stenosis Patrick T. O'Gara, Joseph Loscalzo
- 259 Mitral Regurgitation Patrick T. O'Gara, Joseph Loscalzo
- 260 Mitral Valve Prolapse Patrick T. O'Gara, Joseph Loscalzo
- 261 Tricuspid Valve Disease Patrick T. O'Gara, Joseph Loscalzo
- 262 Pulmonic Valve Disease Patrick T. O'Gara, Joseph Loscalzo
- 263 Multiple and Mixed Valvular Heart Disease Patrick T. O'Gara, Joseph Loscalzo
- 264 Congenital Heart Disease in the Adult Anne Marie Valente, Michael J. Landzberg
- 265 Pericardial Disease Eugene Braunwald
- 266 Atrial Myxoma and Other Cardiac Tumors Eric H. Awtry Section 5: Coronary and Peripheral Vascular Disease
- 267 Ischemic Heart Disease Elliott Antman, Joseph Loscalzo
- 268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina) Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald
- 269 ST-Segment Elevation Myocardial Infarction Elliott M. Antman, Joseph Loscalzo
- 270 Percutaneous Coronary Interventions and Other Interventional Procedures David P. Faxon, Deepak L. Bhatt
- 271 Hypertensive Vascular Disease Theodore A. Kotchen
- 272 Renovascular Disease Stephen C. Textor
- 273 Deep Venous Thrombosis and Pulmonary Thromboembolism Samuel Z. Goldhaber
- 274 Diseases of the Aorta Mark A. Creager, Joseph Loscalzo
- 275 Arterial Diseases of the Extremities Mark A. Creager, Joseph Loscalzo
- 276 Chronic Venous Disease and Lymphedema Mark A. Creager, Joseph Loscalzo
- 277 Pulmonary Hypertension Aaron B. Waxman, Joseph Loscalzo
- Part 7: Disorders of the Respiratory System
- Section 1: Diagnosis of Respiratory Disorders
- 278 Approach to the Patient with Disease of the Respiratory System Patricia A. Kritek, Bruce D. Levy
- 279 Disturbances of Respiratory Function Edward T. Naureckas, Julian Solway
- 280 Diagnostic Procedures in Respiratory Disease Anne L. Fuhlbrigge, Augustine M.K. Choi
- Section 2: Diseases of the Respiratory System
- 281 Asthma Peter J. Barnes
- 282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Praveen Akuthota, Michael E. Wechsler
- 283 Occupational and Environmental Lung Disease John R. Balmes
- 284 Bronchiectasis Rebecca M. Baron, Miriam Baron Barshak
- 285 Cystic Fibrosis Eric J. Sorscher
- 286 Chronic Obstructive Pulmonary Disease Edwin K. Silverman, James D. Crapo, Barry Make
- 287 Interstitial Lung Disease Gary M. Hunninghake, Ivan O. Rosas
- 288 Disorders of the Pleura Richard W. Light
- 289 Disorders of the Mediastinum Richard W. Light
- 290 Disorders of Ventilation John F. McConville, Julian Solway, Babak Mokhlesi
- 291 Sleep Apnea Andrew Wellman, Susan Redline
- 292 Lung Transplantation Elbert P. Trulock,
- III Part 8: Critical Care Medicine
- Section 1: Respiratory Critical Care
- 293 Approach to the Patient with Critical Illness John P. Kress, Jesse B. Hall
- 294 Acute Respiratory Distress Syndrome Rebecca M. Baron, Bruce D. Levy
- 295 Mechanical Ventilatory Support Bartolome R. Celli
- Section 2: Shock and Cardiac Arrest
- 296 Approach to the Patient with Shock Anthony F. Massaro
- 297 Sepsis and Septic Shock Christopher W. Seymour, Derek C. Angus
- 298 Cardiogenic Shock and Pulmonary Edema David H. Ingbar, Holger Thiele
- 299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Christine M. Albert, William G. Stevenson
- Section 3: Neurologic Critical Care
- 300 Coma S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser
- 301 Severe Acute Encephalopathies and Critical Care Weakness J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress
- 302 Subarachnoid Hemorrhage J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress
- Part 9: Disorders of the Kidney and Urinary Tract
- 303 Cellular and Molecular Biology of the Kidney Alfred L. George, Jr., Eric G. Neilson
- 304 Acute Kidney Injury Sushrut S. Waikar, Joseph V. Bonventre
- 305 Chronic Kidney Disease Joanne M. Bargman, Karl L. Skorecki
- 306 Dialysis in the Treatment of Renal Failure Kathleen D. Liu, Glenn M. Chertow
- 307 Transplantation in the Treatment of Renal Failure Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker
- 308 Glomerular Diseases Julia B. Lewis, Eric G. Neilson
- 309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development Jing Zhou, Martin R. Pollak
- 310 Tubulointerstitial Diseases of the Kidney Laurence H. Beck, Jr., David J. Salant
- 311 Vascular Injury to the Kidney Ronald S. Go, Nelson Leung
- 312 Nephrolithiasis Gary C. Curhan
- 313 Urinary Tract Obstruction Julian L. Seifter
- Part 10: Disorders of the Gastrointestinal System
- Section 1: Disorders of the Alimentary Tract
- 314 Approach to the Patient with Gastrointestinal Disease William L. Hasler, Chung Owyang
- 315 Gastrointestinal Endoscopy Louis Michel Wong Kee Song, Mark Topazian
- 316 Diseases of the Esophagus Peter J. Kahrilas, Ikuo Hirano
- 317 Peptic Ulcer Disease and Related Disorders John Del Valle
- 318 Disorders of Absorption Henry J. Binder
- 319 Inflammatory Bowel Disease Sonia Friedman, Richard S. Blumberg
- 320 Irritable Bowel Syndrome Chung Owyang
- 321 Diverticular Disease and Common Anorectal Disorders Rizwan Ahmed, Susan L. Gearhart
- 322 Mesenteric Vascular Insufficiency Satinderjit Locham, Mahmoud Malas
- 323 Acute Intestinal Obstruction Danny O. Jacobs
- 324 Acute Appendicitis and Peritonitis Danny O. Jacobs
- Section 2: Nutrition
- 325 Nutrient Requirements and Dietary Assessment Johanna Dwyer
- 326 Vitamin and Trace Mineral Deficiency and Excess Paolo M. Suter, Robert M. Russell
- 327 Malnutrition and Nutritional Assessment Gordon L. Jensen
- 328 Enteral and Parenteral Nutrition L. John Hoffer, Bruce R. Bistrian, David F. Driscoll
- Section 3: Liver and Biliary Tract Disease
- 329 Approach to the Patient with Liver Disease Marc G. Ghany, Jay H. Hoofnagle
- 330 Evaluation of Liver Function Daniel S. Pratt
- 331 The Hyperbilirubinemias Allan W. Wolkoff
- 332 Acute Viral Hepatitis Jules L. Dienstag
- 333 Toxic and Drug-Induced Hepatitis William M. Lee, Jules L. Dienstag
- 334 Chronic Hepatitis Jules L. Dienstag
- 335 Alcoholic Liver Disease Mark E. Mailliard, Michael F. Sorrell
- 336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis Manal F. Abdelmalek, Anna Mae Diehl
- 337 Cirrhosis and Its Complications Bruce R. Bacon
- 338 Liver Transplantation Raymond T. Chung, Jules L. Dienstag
- 339 Diseases of the Gallbladder and Bile Ducts Norton J. Greenberger, Gustav Paumgartner
- Section 4: Disorders of the Pancreas
- 340 Approach to the Patient with Pancreatic Disease Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks
- 341 Acute and Chronic Pancreatitis Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger
- Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
- Section 1: The Immune System in Health and Disease
- 342 Introduction to the Immune System Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci
- 343 The Major Histocompatibility Complex Gerald T. Nepom
- 344 Primary Immune Deficiency Diseases Alain Fischer
- Section 2: Disorders of Immune-Mediated Injury
- 345 Urticaria, Angioedema, and Allergic Rhinitis Katherine N. Cahill, Joshua A. Boyce
- 346 Anaphylaxis David Hong, Joshua A. Boyce
- 347 Mastocytosis Cem Akin, Joshua A. Boyce
- 348 Autoimmunity and Autoimmune Diseases Betty Diamond, Peter E. Lipsky
- 349 Systemic Lupus Erythematosus Bevra Hannahs Hahn
- 350 Antiphospholipid Syndrome Haralampos M. Moutsopoulos
- 351 Rheumatoid Arthritis Ankoor Shah, E. William St. Clair
- 352 Acute Rheumatic Fever Jonathan R. Carapetis
- 353 Systemic Sclerosis (Scleroderma) and Related Disorders John Varga
- 354 Sjogren's Syndrome Haralampos M. Moutsopoulos
- 355 The Spondyloarthritides Joel D. Taurog
- 356 The Vasculitis Syndromes Carol A. Langford, Anthony S. Fauci
- 357 Behcet's Syndrome Haralampos M. Moutsopoulos
- 358 Inflammatory Myopathies Steven A. Greenberg, Anthony A. Amato
- 359 Relapsing Polychondritis Carol A. Langford
- 360 Sarcoidosis Robert P. Baughman, Elyse E. Lower
- 361 IgG4-Related Disease John H. Stone
- 362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases Daniel L. Kastner
- Section 3: Disorders of the Joints and Adjacent Tissues
- 363 Approach to Articular and Musculoskeletal Disorders John J. Cush
- 364 Osteoarthritis David T. Felson, Tuhina Neogi
- 365 Gout and Other Crystal-Associated Arthropathies H. Ralph Schumacher, Lan X. Chen
- 366 Fibromyalgia Leslie J. Crofford
- 367 Arthritis Associated with Systemic Disease, and Other Arthritides Carol A. Langford, Brian F. Mandell
- 368 Periarticular Disorders of the Extremities Carol A. Langford
- Part 12: Endocrinology and Metabolism
- Section 1: Endocrinology
- 369 Approach to the Patient with Endocrine Disorders J. Larry Jameson
- 370 Mechanisms of Hormone Action J. Larry Jameson
- 371 Physiology of Anterior Pituitary Hormones Shlomo Melmed, J. Larry Jameson
- 372 Hypopituitarism Shlomo Melmed, J. Larry Jameson
- 373 Pituitary Tumor Syndromes Shlomo Melmed, J. Larry Jameson
- 374 Disorders of the Neurohypophysis Gary L. Robertson
- 375 Thyroid Gland Physiology and Testing J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
- 376 Hypothyroidism J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
- 377 Hyperthyroidism J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
- 378 Thyroid Nodular Disease and Thyroid Cancer J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
- 379 Disorders of the Adrenal Cortex Wiebke Arlt
- 380 Pheochromocytoma Hartmut P. H. Neumann
- 381 Multiple Endocrine Neoplasia R. V. Thakker
- 382 Autoimmune Polyendocrine Syndromes Peter A. Gottlieb, Aaron W. Michels
- Section 2: Sex- and Gender-Based Medicine
- 383 Disorders of Sex Development John C. Achermann, J. Larry Jameson
- 384 Disorders of the Testes and Male Reproductive System Shalender Bhasin, J. Larry Jameson
- 385 Disorders of the Female Reproductive System Janet E. Hall
- 386 Menstrual Disorders and Pelvic Pain Janet E. Hall
- 387 Hirsutism David A. Ehrmann
- 388 Menopause and Postmenopausal Hormone Therapy JoAnn E. Manson, Shari S. Bassuk
- 389 Infertility and Contraception Janet E. Hall
- 390 Sexual Dysfunction Kevin T. McVary
- 391 Women's Health Andrea Dunaif
- 392 Men's Health Shalender Bhasin, Shehzad Basaria
- 393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health Baligh R. Yehia, Harvey J. Makadon
- Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
- 394 Pathobiology of Obesity Jeffrey S. Flier, Eleftheria Maratos-Flier
- 395 Evaluation and Management of Obesity Robert F. Kushner
- 396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology Alvin C. Powers, Kevin D. Niswender, Carmella Evans-Molina
- 397 Diabetes Mellitus: Management and Therapies Alvin C. Powers, Kevin D. Niswender, Michael R. Rickels
- 398 Diabetes Mellitus: Complications Alvin C. Powers, John M. Stafford, Michael R. Rickels
- 399 Hypoglycemia Philip E. Cryer, Stephen N. Davis
- 400 Disorders of Lipoprotein Metabolism Daniel J. Rader, Sekar Kathiresan
- 401 The Metabolic Syndrome Robert H. Eckel
- Section 4: Disorders of Bone and Mineral Metabolism</li>
- 402 Bone and Mineral Metabolism in Health and Disease F. Richard Bringhurst, Marie B. Demay, Henry M. Kronenberg
- 403 Disorders of the Parathyroid Gland and Calcium Homeostasis John T. Potts, Jr., Harald Juppner
- 404 Osteoporosis Robert Lindsay, Felicia Cosman
- 405 Paget's Disease and Other Dysplasias of Bone Murray J. Favus, Tamara J. Vokes
- Section 5: Disorders of Intermediary Metabolism
- 406 Heritable Disorders of Connective Tissue Darwin J. Prockop, John F. Bateman
- 407 Hemochromatosis Lawrie W. Powell
- 408 Wilson's Disease George J. Brewer
- 409 The Porphyrias Robert J. Desnick, Manisha Balwani
- 410 Disorders of Purine and Pyrimidine Metabolism John N. Mecchella, Christopher M. Burns
- 411 Lysosomal Storage Diseases Robert J. Hopkin, Gregory A. Grabowski
- 412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism Priya S. Kishnani, Yuan-Tsong Chen
- 413 Inherited Disorders of Amino Acid Metabolism in Adults Nicola Longo
- 414 Inherited Defects of Membrane Transport Nicola Longo
- Part 13: Neurologic Disorders
- Section 1: Diagnosis of Neurologic Disorders
- 415 Approach to the Patient with Neurologic Disease Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser
- 416 Neuroimaging in Neurologic Disorders William P. Dillon
- 417 Pathobiology of Neurologic Diseases Stephen L. Hauser, Arnold R. Kriegstein, Stanley B. Prusiner
- Section 2: Diseases of the Central Nervous System
- 418 Seizures and Epilepsy Daniel H. Lowenstein
- 419 Cerebrovascular Diseases Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
- 420 Ischemic Stroke Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
- 421 Intracranial Hemorrhage Wade S. Smith, J. Claude Hemphill, III, S. Claiborne Johnston
- 422 Migraine and Other Primary Headache Disorders Peter J. Goadsby
- 423 Alzheimer's Disease William W. Seeley, Bruce L. Miller
- 424 Frontotemporal Dementia William W. Seeley, Bruce L. Miller
- 425 Vascular Dementia Joel H. Kramer, William W. Seeley, Bruce L. Miller
- 426 Dementia with Lewy Bodies William W. Seeley, Caroline M. Tanner, Bruce L. Miller
- 427 Parkinson's Disease C. Warren Olanow, Christine Klein, Anthony H. V. Schapira
- 428 Tremor, Chorea, and Other Movement Disorders C. Warren Olanow, Christine Klein, Jose A. Obeso
- 429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr.
- 430 Prion Diseases Stanley B. Prusiner, Bruce L. Miller
- 431 Ataxic Disorders Roger N. Rosenberg
- 432 Disorders of the Autonomic Nervous System Christopher H. Gibbons, John W. Engstrom
- 433 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders M. Flint Beal, Stephen L. Hauser
- 434 Diseases of the Spinal Cord Stephen L. Hauser
- 435 Concussion and Other Traumatic Brain Injuries Geoffrey T. Manley, Stephen L. Hauser, Michael McCrea
- 436 Multiple Sclerosis Bruce A. C. Cree, Stephen L. Hauser
- 437 Neuromyelitis Optica Bruce A. C. Cree, Stephen L. Hauser
- Section 3: Nerve and Muscle Disorders
- 438 Peripheral Neuropathy Anthony A. Amato, Richard J. Barohn
- 439 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies Stephen L. Hauser, Anthony A. Amato
- 440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction Anthony A. Amato
- 441 Muscular Dystrophies and Other Muscle Diseases Anthony A. Amato, Robert H. Brown, Jr.
- Section 4: Chronic Fatigue Syndrome
- 442 Chronic Fatigue Syndrome Gijs Bleijenberg, Jos W. M. van der Meer
- Section 5: Psychiatric and Addiction Disorders
- 443 Biology of Psychiatric Disorders Robert O. Messing, Eric J. Nestler, Matthew W. State
- 444 Psychiatric Disorders Victor I. Reus
- 445 Alcohol and Alcohol Use Disorders Marc A. Schuckit
- 446 Opioid-Related Disorders Thomas R. Kosten, Colin N. Haile
- 447 Cocaine and Other Commonly Used Drugs Karran A. Phillips, Antonello Bonci
- 448 Nicotine Addiction David M. Burns
- Part 14: Poisoning, Drug Overdose, and Envenomation
- 449 Heavy Metal Poisoning Howard Hu
- 450 Poisoning and Drug Overdose Mark B. Mycyk
- 451 Disorders Caused by Venomous Snakebites and Marine Animal Exposures Charles Lei, Kirsten B. Hornbeak, Paul S. Auerbach, Robert L. Norris
- 452 Ectoparasite Infestations and Arthropod Injuries Richard J. Pollack, Scott A. Norton
- Part 15: Disorders Associated with Environmental Exposures
- 453 Altitude Illness Buddha Basnyat, Geoffrey Tabin
- 454 Hypothermia and Peripheral Cold Injuries Daniel F. Danzl
- 455 Heat-Related Illnesses Daniel F. Danzl
- Part 16: Genes, the Environment, and Disease
- 456 Principles of Human Genetics J. Larry Jameson, Peter Kopp
- 457 The Practice of Genetics in Clinical Medicine Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt
- 458 Gene and Cell Based Therapy in Clinical Medicine Katherine A. High, Malcolm K. Brenner
- 459 The Human Microbiome Neeraj K. Surana, Dennis L. Kasper
- Part 17: Global Medicine
- 460 Global Issues in Medicine Joseph J. Rhatigan, Paul Farmer
- 461 Worldwide Changes in Patterns of Infectious Disease George W. Rutherford, Jaime Sepulveda
- 462 Primary Care and Global Health Tim Evans, Kumanan Rasanathan
- Part 18: Aging
- 463 The Biology of Aging Rafael de Cabo, David G. Le Couteur
- 464 Clinical Problems Associated with the Aging Process Joseph G. Ouslander, Bernardo Reyes
- Part 19: Consultative Medicine
- 465 Approach to Medical Consultation Jack Ende, Jeffrey Berns
- 466 Medical Disorders During Pregnancy Robert L. Barbieri, John T. Repke
- 467 Medical Evaluation of the Surgical Patient Prashant Vaishnava, Kim A. Eagle
- Part 20: Frontiers
- 468 Behavioral Economics and Health Kevin G. Volpp, George Loewenstein, David A. Asch
- 469 Complementary, Alternative, and Integrative Health Approaches Josephine P. Briggs
- 470 Telomere Disease Rodrigo T. Calado, Neal S. Young
- 471 The Role of Epigenetics in Disease and Treatment Brian C. Capell, Shelley L. Berger
- 472 Mitochondrial DNA and Heritable Traits and Diseases Karl L. Skorecki, Bruce H. Cohen
- 473 Applications of Stem Cell Biology in Clinical Medicine John A. Kessler
- 474 Microbial Genomics and Infectious Disease Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung
- 475 The Role of Circadian Biology in Health and Disease Jonathan Cedernaes, Kathryn Moynihan Ramsey, Joseph Bass
- 476 Network Medicine: Systems Biology in Health and Disease Joseph Loscalzo
- 477 Emerging Neurotherapeutic Technologies Jyoti Mishra, Karunesh Ganguly Online Chapters The following chapters are available online. They can be viewed at www.accessmedicine.com.
- Part 21: Video Collection
- V1 Video Library of Gait Disorders Gail Kang, Nicholas B. Galifianakis, Michael D. Geschwind
- V2 Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders Maria Luisa Gorno-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia
- V3 Video Library of Neuro-Ophthalmology Jonathan C. Horton
- V4 Examination of the Comatose Patient S. Andrew Josephson
- V5 Video Atlas of Gastrointestinal Endoscopic Lesions Louis Michel Wong Kee Song, Mark Topazian
- V6 The Neurologic Screening Exam Daniel H. Lowenstein
- V7 Video Atlas of the Detailed Neurologic Examination Martin A. Samuels
- Part 22: Supplementary Topics
- S1 Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples David B. Mount, Thomas D. DuBose, Jr.
- S2 Microbial Bioterrorism H. Clifford Lane, Anthony S. Fauci
- S3 Chemical Terrorism Jonathan Newmark, James A. Romano, Jr.
- S4 Radiation Terrorism Christine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner
- S5 Infections in War Veterans Andrew W. Artenstein
- S6 Health Care for Military Veterans Stephen C. Hunt, Charles W. Hoge
- S7 Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases Alain Fischer
- S8 Cardiac Trauma Eric H. Awtry
- S9 Technique of Lumbar Puncture Elizabeth Robbins, Stephen L. Hauser
- S10 Classification of the Spinocerebellar Ataxias Roger N. Rosenberg
- S11 Hyperbaric and Diving Medicine Michael H. Bennett, Simon J. Mitchell
- S12 The Clinical Laboratory in Modern Health Care Anthony A. Killeen
- S13 Laboratory Diagnosis of Infectious Diseases Alexander J. McAdam, Andrew B. Onderdonk
- S14 Laboratory Diagnosis of Parasitic Infections Sharon L. Reed, Charles E. Davis
- Part 23: Atlases
- A1 Atlas of Rashes Associated with Fever Kenneth M. Kaye, Elaine T. Kaye
- A2 Atlas of Oral Manifestations of Disease Samuel C. Durso, Janet A. Yellowitz
- A3 Atlas of Urinary Sediments and Renal Biopsies Agnes B. Fogo, Eric G. Neilson
- A4 Atlas of Skin Manifestations of Internal Disease Thomas J. Lawley, Benjamin K. Stoff, Calvin O. McCall
- A5 Atlas of Hematology Dan L. Longo
- A6 Atlas of Blood Smears of Malaria and Babesiosis Nicholas J. White, Joel G. Breman
- A7 Atlas of Electrocardiography Ary L. Goldberger
- A8 Atlas of Noninvasive Imaging Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon
- A9 Atlas of Cardiac Arrhythmias Ary L. Goldberger
- A10 Atlas of Atherosclerosis Peter Libby
- A11 Atlas of Percutaneous Revascularization Jane A. Leopold, Deepak L. Bhatt, David P. Faxon
- A12 Atlas of Chest Imaging Patricia A. Kritek, John J. Reilly, Jr.
- A13 Atlas of Liver Biopsies Jules L. Dienstag, Atul K. Bhan
- A14 Atlas of the Vasculitic Syndromes Carol A. Langford, Anthony S. Fauci
- A15 Atlas of Clinical Manifestations of Metabolic Diseases J. Larry Jameson
- A16 Atlas of Neuroimaging Andre D. Furtado, Luciano Villarinho, William P. Dillon Index I-1Б.
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