Last edition Elsevier Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.
Last Edition
ISBN 13:h9780128033692
Imprint:hAcademic Press
Language:<hEnglish
Authors:hChaim Putterman
Pub Date:h05/2018
Pages:h186
Illus:hIllustrated
Weight:h320.000 grams
Size:h152 X 229 mm
Product Type:hSoftcover
| List Price |
| grn 3973 |
| $ 130,27 |
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- • Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
- • Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
- • Features a collaborative editorial effort, involving clinical immunologists and structural biologists
- • Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
- • Gives interested parties a bridge to learn about computer modeling and structure based design principles.
- Chaim Putterman, Albert Einstein College of Medicine, Bronx, NY, USA;
- David Cowburn, Departments of Biochemistry, Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
- Steven Almo, Departments of Biochemistry, Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
- 1. Organization of Immunological Synapses and Kinapses
- 2. Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors
- 3. Synthetic Antibody Engineering: Concepts and Applications
- 4. Natural Killer Cell Receptor
- 5. Structure-Function in Antibodies to Double-Stranded DNA
- 6. The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure
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